High-performance nanoparticles for LFIA
Poly-Dtech offers a specialized range of lanthanide-based fluorescent nanoparticles based on Europium and Terbium, specifically engineered for Lateral Flow Immunoassays (LFIA). Thanks to their intense fluorescence and long-lifetime emission, these labels provide high signal-to-background performance and enable sensitivity detection, including at low analyte concentrations.
Why choose Poly-Dtech for your lateral flow tests?
Integrating Bright-Dtech™ or Link-Dtech™ nanoparticles into your LFA can enhance detection sensitivity while keeping assay development and conjugation protocols straightforward. Whether you are developing an OEM diagnostic kit, advancing R&D, or upgrading existing assay, Poly-Dtech provide solutions to support your development from proof of concept to scale-up.
Our key advantages:
• Enhanced sensitivity compared with conventional visual labels such as gold and latex
• High-performance detection suitable for demanding diagnostic applications
• Industrial-grade reproducibility
• Multiplex detection using nanoparticles with distinct lanthanide emission profiles on a single strip
Publications
Our technology has been evaluated in peer-reviewed research, with ongoing collaborative studies exploring further applications:
- Lanthanide nanoparticles as ultra-sensitive luminescent probes for quantitative PSA detection via lateral flow assays. Juliette Lajoux, Mohamadou Sy, Loïc J. Charbonnière, Joan Goetz, Susana Brun. Sensors & Diagnostics, 2025, 5 (1): 76-82. doi: https://doi.org/10.1039/d5sd00143a
- Breaking the picomolar barrier in lateral flow assays using Bright-Dtech™ 614 – Europium nanoparticles for enhanced sensitivity. Juliette Lajoux, Yulieth D. Banguera-Ordoñez, Amadeo Sena-Torralba, Loïc J. Charbonnière, Mohamadou Sy, Joan Goetz, Ángel Maquieira, Sergi Morais. Microchemical Journal, 2025, Volume 209, 112864. doi: https://doi.org/10.1016/j.microc.2025.112864
- Ultrabright Terbium Nanoparticles for FRET Biosensing and In Situ Imaging of Epidermal Growth Factor Receptors. Cyrille Charpentier, Vjona Cifliku, Joan Goetz, Aline Nonat, Clémence Cheignon, Marcelina Cardoso Dos Santos, Laura Francés-Soriano, Ka-Leung Wong, Loïc J Charbonnière, Niko Hildebrandt. Chemistry. 2020 Nov 17;26(64):14602-14611. doi: 10.1002/chem.202002007
- Live cell imaging without autofluorescence using terbium nanoparticles. Joan Goetz, Marcelina Cardoso Dos Santos, Ka-Leung Wong, Loïc J Charbonnière, Niko Hildebrandt, Hortense Bertenlian. Bioconjugate Chem. 2018, 29, 4, 1327–1334. doi: 10.1021/acs.bioconjchem.8b00069
Ready to Upgrade Your LFIA?
Explore our Bright-Dtech™ and Link-Dtech™ solutions, specifically engineered for LFIA, for sensitive fluorescence-based detection and customized nanoparticle conjugates:
Bright-Dtech™ 614 – Eu (Red) – For LFIA
Choose our ready-to-use biological conjugates, supplied with buffers and conjugated Europium nanoparticles, for sensitive fluorescence-based detection in LFIA.
- Available volumes: 250 µL, 500 µL, 1.5 mL, and 6 mL
Bright-Dtech™ 545 – Tb (Green) – For LFIA
Choose our ready-to-use biological conjugates, supplied with buffers and conjugated Terbium nanoparticles, for sensitive fluorescence-based detection in LFIA.
- Available volumes: 250 µL, 500 µL, 1.5 mL, and 6 mL
Link-Dtech™ 614 – Eu (Red) – For LFIA
Choose our biological conjugation kit, supplied with buffer and Europium nanoparticles, for the preparation of customized fluorescent nanoparticle conjugates for LFIA.
- Available volumes: 200 µL, 2 mL, and 8 mL
Link-Dtech™ 545 – Tb (Green) – For LFIA
Choose our biological conjugation kit, supplied with buffer and Terbium nanoparticles, for the preparation of customized fluorescent nanoparticle conjugates for LFIA.
- Available volumes: 200 µL, 2 mL, and 8 mL
To visualize or quantify the fluorescent signal in your LFIA, an appropriate fluorescence detection system is required, this may include an UV excitation source (around 340 nm), or a time-resolved fluorescence reader. These systems enable sensitive detection of test and control lines and support semi-quantitative or quantitative analysis of samples.
Feel free to contact our team for recommendations, or visit our Applications (Applications) and Custom Services (Services) pages to discover how Poly-Dtech can support your assay development.