CDX2 Monoclonal Antibody (14H6)

Description

Data sheet CDX2 Monoclonal Antibody (14H6)

 

Background: This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

Purification: Affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml

Formulation: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Molecular weight: 37408

Gene ID: Human: 968; Mouse: 12514

Synonyms: CD68; Macrosialin; Gp110; CD68

Research area:Immunology; Microbiology

Target protein: CD68